Tag: Obesity

THE MATADOR STUDY:Minimising Adaptive Thermogenesis And Deactivating Obesity Rebound

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The MATADOR (Minimising Adaptive Thermogenesis And Deactivating Obesity Rebound) study

Source: International Journal of Obesity – Abstract of article: Intermittent energy restriction improves weight loss efficiency in obese men: the MATADOR study


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Gut bacteria & obesity

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Add “metabolism” to the laundry list of things your microbiome can affect.

Source: Gut bacteria might be tied to obesity


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Eating Fast May Raise Obesity Risk

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Going to sleep within two hours of eating dinner and snacking after dinner were also associated with obesity, but skipping breakfast was not.

Source: Eating Fast May Raise Obesity Risk


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Obesity drives U.S. health care costs up by 29 percent

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Recent research provides new insights on how individual states are affected by the health care costs of obesity.

Source: Obesity drives U.S. health care costs up by 29 percent, varies by state


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A Budgetary Impact Analysis of Medicare Coverage for AntiObesity Interventions

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Key Findings
 IHS Markit used a validated and published individual simulation model to predict the budget
impact to Medicare coverage utilization of anti-obesity interventions
 Over the next 10 years, Medicare is expected to save $19 billion after a modest coverage
utilization, and $21 billion after a more aggressive coverage utilization, with the majority of the
savings coming from reduction in ambulatory care (Part B) and prescription drug (Part D)
expenditures
 Even after an aggressive (67.4%) coverage utilization, the evidence shows ≤8% of all Medicare
beneficiaries to receive some form of anti-obesity treatment
 The analysis demonstrates on average, lifestyle intervention helps elderly who are eligible lose
7.5% of excessive weight per year, and anti-obesity drug combined with lifestyle intervention can
help eligible patients lose about 9.7%. Participants regain 1/3 of initial lost weight within 5 years
after discontinuation
 The data show that each treated beneficiary is expected to incur direct costs to Medicare of
~$1,700 from covered anti-obesity treatment. Those costs will be offset by improvement in their
overall health condition, leading to lower expenditures in ER, ambulatory care, inpatient stays,
and Rx, resulting in net savings between $6,700 – $7,100 over 10 years per person
 Model estimates across the entire Medicare population suggest medical expense would increase
about $120 per beneficiary due to higher coverage utilization. The reduction in the cost of
treating obesity complications would be more than enough to offset the increased expense,
leading to a net savings of between $300 – $330 per beneficiary over 10 years

Source: Budget Report


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Losing Weight Eases Obesity-Related Pain

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A study in the Journal of Pain found obese patients who lost 10% of their body weight reported less pain, in expected locations such as joints and in non-weight-bearing areas such as the abdomen, arm, chest and jaw. “What we think that means is this process of losing weight may be affecting the central mechanisms of pain control related to the brain and spinal cord,” said researcher Andrew Schrepf.

Source: Losing Weight Eases Obesity-Related Pain. But How Much Is Enough?


Pain Sensitization Declines After Bariatric Tx in Obese Patients

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Decreased knee pain linked with central sensitization

Source: Pain Sensitization Declines After Bariatric Tx in Obese Patients


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KSR2 Mutations Are Associated with Obesity, Insulin Resistance, and Impaired Cellular Fuel Oxidation

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Mutation carriers exhibit hyperphagia in childhood, low heart rate, reduced basal metabolic rate and severe insulin resistance. These data establish KSR2 as an important regulator of energy intake, energy expenditure, and substrate utilization in humans. Modulation of KSR2-mediated effects may represent a novel therapeutic strategy for obesity and type 2 diabetes.

Source: KSR2 Mutations Are Associated with Obesity, Insulin Resistance, and Impaired Cellular Fuel Oxidation


The genetics of obesity: FTO leads the way

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 The association between FTO SNPs and BMI and the risk of being overweight or obese has been confirmed in multiple populations [6,7,9–27]. The effect of FTO SNPs on BMI is modest, with those individuals homozygous for the risk allele weighing, on average, 3 kg more than those homozygous for the protective allele [7].

Source: The genetics of obesity: FTO leads the way


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Eating Too Quickly Is Linked to Obesity and Metabolic Syndrome | Time

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Eating too fast is linked to obesity and metabolic syndrome, according to a new study. Slow eating, it turns out, is healthier.

Source: Eating Too Quickly Is Linked to Obesity and Metabolic Syndrome | Time


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Gene Prompts Cells to Store Fat, Fueling Obesity

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Obesity is often attributed to a simple equation: People are eating too much and exercising too little. But evidence is growing that at least some of the weight gain that plagues modern humans is predetermined. New research from the Research Triangle suggests that variants in a gene called ankyrin-B — carried by millions of Americans — could cause people to put on pounds through no fault of their own.

Source: Gene Prompts Cells to Store Fat, Fueling Obesity | Duke Today


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Intermittent fasting may help fight obesity – UPI.com

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Researchers have determined that up to 16 weeks of intermittent fasting without calorie counting can help fight obesity and metabolic diseases.

Source: Intermittent fasting may help fight obesity – UPI.com


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Overweight & Obesity Statistics | NIDDK

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Describes the prevalence of overweight and obesity among adults in the United States by providing statistics.

Source: Overweight & Obesity Statistics | NIDDK


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