Ehlers–Danlos syndrome is a rare disorder, comprising a group of related inheriteddisorders of connective tissue, resulting from underlying abnormalities in the synthesisand metabolism of collagen. This proposal is specifically concerned with Ehlers–Danlossyndrome classic type (formerly Types I–III), which is characterized by joint hypermobilityand susceptibility to injury/arthritis, skin and vascular problems (including easybruising, bleeding, varicose veins and poor tissue healing), cardiac mitral valveprolapse, musculo-skeletal problems (myopathy, myalgia, spinal scoliosis, osteoporosis),and susceptibility to periodontitis.